Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey
Identifieur interne : 00B764 ( Main/Exploration ); précédent : 00B763; suivant : 00B765Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey
Auteurs : Dan Engelhard [Israël] ; Catherine Cordonnier [France] ; Peter J. Shaw [Australie] ; Terttu Parkalli [Finlande] ; Christine Guenther [Allemagne] ; Rodrigo Martino [Espagne] ; Adriaan W. Dekker [Pays-Bas] ; H. Grant Prentice [Royaume-Uni] ; Anita Gustavsson [Suède] ; Wenzel Nurnberger [Allemagne] ; Per Ljungman [Suède]Source :
- British journal of haematology [ 0007-1048 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cellule souche, Homme.
English descriptors
- KwdEn :
Abstract
Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (≥ 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P<0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P <0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization.
Affiliations:
- Allemagne, Australie, Espagne, Finlande, France, Israël, Pays-Bas, Royaume-Uni, Suède
- Angleterre, Bavière, Catalogne, District de Düsseldorf, District de Haute-Bavière, Grand Londres, Nouvelle-Galles du Sud, Rhénanie-du-Nord-Westphalie, Utrecht (province), Île-de-France
- Barcelone, Créteil, Düsseldorf, Londres, Munich, Sydney, Utrecht
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Mondor Hospital</s1><s2>Creteil</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J." last="Shaw">Peter J. Shaw</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>New Children's Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Parkalli, Terttu" sort="Parkalli, Terttu" uniqKey="Parkalli T" first="Terttu" last="Parkalli">Terttu Parkalli</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>4 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki University Central Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Guenther, Christine" sort="Guenther, Christine" uniqKey="Guenther C" first="Christine" last="Guenther">Christine Guenther</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Klinikum Grosshadern</s1><s2>Munich</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hospital de Sant Pau</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Dekker, Adriaan W" sort="Dekker, Adriaan W" uniqKey="Dekker A" first="Adriaan W." last="Dekker">Adriaan W. Dekker</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University Hospital</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Prentice, H Grant" sort="Prentice, H Grant" uniqKey="Prentice H" first="H. Grant" last="Prentice">H. Grant Prentice</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>The Royal Free and University College Medical School and Royal Free Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gustavsson, Anita" sort="Gustavsson, Anita" uniqKey="Gustavsson A" first="Anita" last="Gustavsson">Anita Gustavsson</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nurnberger, Wenzel" sort="Nurnberger, Wenzel" uniqKey="Nurnberger W" first="Wenzel" last="Nurnberger">Wenzel Nurnberger</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Heinrich Heine University</s1><s2>Düsseldorf</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Ljungman, Per" sort="Ljungman, Per" uniqKey="Ljungman P" first="Per" last="Ljungman">Per Ljungman</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Huddinge University Hospital</s1><s2>Huddinge</s2><s3>SWE</s3><sZ>11 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Huddinge University Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autograft</term><term>Bone marrow</term><term>Complication</term><term>Graft versus host reaction</term><term>Hematopoietic cell</term><term>Homograft</term><term>Human</term><term>Late</term><term>Pneumococcal infection</term><term>Stem cell</term><term>Streptococcus pneumoniae</term><term>Survey</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homogreffe</term><term>Autogreffe</term><term>Maladie greffon hôte</term><term>Complication</term><term>Tardif</term><term>Pneumococcie</term><term>Streptococcus pneumoniae</term><term>Cellule hématopoïétique</term><term>Cellule souche</term><term>Moelle osseuse</term><term>Enquête</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (≥ 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P<0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P <0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Israël</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Bavière</li><li>Catalogne</li><li>District de Düsseldorf</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Rhénanie-du-Nord-Westphalie</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Créteil</li><li>Düsseldorf</li><li>Londres</li><li>Munich</li><li>Sydney</li><li>Utrecht</li></settlement></list><tree><country name="Israël"><noRegion><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J." last="Shaw">Peter J. Shaw</name></region></country><country name="Finlande"><noRegion><name sortKey="Parkalli, Terttu" sort="Parkalli, Terttu" uniqKey="Parkalli T" first="Terttu" last="Parkalli">Terttu Parkalli</name></noRegion></country><country name="Allemagne"><region name="Bavière"><name sortKey="Guenther, Christine" sort="Guenther, Christine" uniqKey="Guenther C" first="Christine" last="Guenther">Christine Guenther</name></region><name sortKey="Nurnberger, Wenzel" sort="Nurnberger, Wenzel" uniqKey="Nurnberger W" first="Wenzel" last="Nurnberger">Wenzel Nurnberger</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Dekker, Adriaan W" sort="Dekker, Adriaan W" uniqKey="Dekker A" first="Adriaan W." last="Dekker">Adriaan W. Dekker</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Prentice, H Grant" sort="Prentice, H Grant" uniqKey="Prentice H" first="H. Grant" last="Prentice">H. Grant Prentice</name></region></country><country name="Suède"><noRegion><name sortKey="Gustavsson, Anita" sort="Gustavsson, Anita" uniqKey="Gustavsson A" first="Anita" last="Gustavsson">Anita Gustavsson</name></noRegion><name sortKey="Ljungman, Per" sort="Ljungman, Per" uniqKey="Ljungman P" first="Per" last="Ljungman">Per Ljungman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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